The Bubbler - The Bubbler kidnaps the Shah of Shish-Ka-Bob and it's up to the Impossible to rescue the Shah.

The Spinner - The Spinner steals a $1,000,000 tiara.

The Perilous Paper Doll - The Paper Doll Man has stolen a top secret plan and is out to steal the second part.

Beamatron - Beamatron steals a priceless painting from a ship.

The Burrower - The Burrower uses his burrowing machine to steal half a million dollars from the bank and dig ten mile down to his lair.

Timeatron - Timeatron uses his powers to bring villains from the past to pillage for him.

Smogula - Smogula freezes the Impossibles and seals them within a cave, so they won't interfere with his plans to conquer Empire City.

The Sinister Speck - The Speck uses a formula to shrink himself in order to photograph some top secret plans.

Fero, The Fiendish Fiddler - To get the Impossibles out of the way, Fero uses his fiddle to transport them to different planets.

Mother Gruesome - Mother Gruesome invents a machine that brings villainous storybook characters out of their stories to help her with her crimes Help Coil Man save way.

Televisatron - Televisatron uses his powers to transport the Impossibles to different television shows Coily and Multi at Fluid Man save it!

The Diabolical Dauber - The Dauber uses a special brush where anything he paints becomes real.

Aquator - Aquator has stolen a secret formula and shrinks himself to microscopic size.

The Wretched Professor Stretch - Professor Stretch is causing havoc with his elastical abilities.

The Devilish Dragster - The Devilish Dragster has stolen a very valuable item.

Satanic Surfer - The Satanic Surfer takes pictures of a top secret submarine.

The Scheming Spraysol - Spraysol is out to steal some top secret documents.

The Scurrilous Sculptor - The Sculptor is turning people into statues.

The Artful Archer - The Artful Archer steals a priceless violin and a million dollars. It's up to the Impossibles to reclaim them.

The Insidious Inflator - The Inflator creates giant balloon monsters to help him commit crimes.

Cronella Critch The Tricky Witch - Cronella Critch has robbed a charity for orphans party.

The Terrible Twister - The Twister is on a crime spree and is stealing precious jewels.

Professor Stretch Bounces Back - Professor Stretch returns and creates a rubber monster to help him in his crimes.

The Terrifying Tapper - The Tapper is a criminal who can transmit himself over the phone lines. He uses this ability to commit crimes.

Billy The Kidder - Billy the Kidder, a cowboy that rides a robotic horse, is planning to rob the U.S. Mint.

The Fiendish Doctor Futuro - The Impossibles fight Doctor Futuro who has come from the fortieth century to their time to steal a million dollar gold brick.

The Crafty Clutcher - The Clutcher uses an invention that brings his gloves to life.

The Infamous Mr. Instant - Mr. Instant uses his insta-gun which can make anything in an instant to help him commit crimes.

The Bizarre Batter - The Batter kidnaps a baseball star and holds him for a ransom of $1,000,000.

The Not So Nice Mr. Ice - Mr. Ice and his assistant Freeze are freezing the city in order to take over it.