Solo investigates a girl's school for the daughters of VIP's, including Miki Matsu, who has valuable secret information from her father, a Japanese diplomat. THRUSH agent Jason Sutro has gained the cooperation of the headmistress, Hester Partridge. The assistant dean, Verity Burgoyne, and all of the girl students have been brainwashed by Sutro to go into a trance upon hearing a recording of Brahm's Lullaby, and are ordered to kill Solo.

Solo is nearly killed by a superhuman, robotlike girl, Margo Hayward, one of an army of such devices invented by Dr. Pertwee for THRUSH. Illya joins up with Margo's ex-roommate, Andy Francis, and finds the laboratory, where a roomful of robots attack them.

In spoof of ""My Fair Lady,"" Solo is recuperating from a fall into a Venice canal, Illya teams with Mark Slate to uncover Baroness Bibi de Chasseur, a THRUSH money courier who has contact with the treasurer of THRUSH. They recruit a barroom entertainer, Rosy Shlagenheimer, an exact double, to impersonate her. The switch is made, but in the confusion the Baroness makes another switch and poses as Rosy, then finds herself falling in love with Slate.

Frank Cariago, the U.S. head of a crime syndicate, is under pressure from Uncle Giuliano. Cariago decides to buy a movie production directed by Sheldon Veblan so his girlfriend, Ginger Laveer can have the starring role. But the picture is a disguised plan to drop a bomb on the family's biggest rival-Las Vegas.

THRUSH agent Abbot Simon takes over the monastery at St. Thomas to use the mountain location to aim a new laser gun at a long distance target the Louvre in Paris. Solo visits the area and meets Andrea Fouchet, and together they try to stop Simon before he destroys the world's greatest art treasures.

A dissatisfied THRUSH collaborator tips U.N.C.L.E. off to a new deadly hiccup gas. A pendant he wears leads Illya to Greenwich Village and an art gallery run by Mark Ole, a THRUSH agent. Starving artist Sylvia Harrison joins Illya, who is nearly suffocated at the hands of a foam producing machine.

Solo and Illya are assigned to protect Dr. Fazie Nahdi, a Gandhi like peace advocate, during a conference. Nellie Canford, a high school teacher, becomes linked to their efforts when her dental work begins receiving radio transmissions. Mahdi stays at the home of Brutus Thor, who is actually a THRUSH leader who is trying to kill him and Illya is trapped in a room full of toys that begin firing real bullets.

Solo and Illya protect Miranda Bryant, the wife of a presidential candidate, from a THRUSH plot to kidnap her, not realizing that she has already been kidnapped and replaced with a double Irina, an unwitting dupe of THRUSH. When they do catch on, the candidate, Senator Bryant and his aide Fairbanks, agree to play along but Fairbanks is the one behind the plot to put a THRUSH agent in the White House.

Solo and Illya go to Algiers to obtain a rare old book containing a THRUSH code from Pierrot La Mouche who has stolen it from his boss, Colonel Hamid. But La Mouche has a high price he wants U.N.C.L.E. to help him obtain Janine whom he is in love with.

An off-broadway actress is murdered during a phone call to U.N.C.L.E., and Solo and Illya investigate a connection between the show and a sudden malfunction in U.N.C.L.E.'s communications. The understudy, Janet Jarrod, takes over the lead role, and Illya joins the cast to find the jamming device.

While in Italy investigating a THRUSH plan to divert the Gulf Stream with heavy water, Solo finds himself eluding THRUSH guards, and ends up hiding under the bed of Pia Monteri. Solo escapes a shotgun wedding, the family feels Pia's honor has been compromised, and the girl's American uncles retired Prohibition-era gangsters ""Fingers"" Stilletto, Enzo ""Pretty"" Stilletto, and Federico ""Feet"" Stilletto are called. At the island headquarters of Louis Strago, Illya is tortured by Strago's sadistic female assistant, Miss Diketon. Solo joins forces with the Stilletto brothers to try and rescue him.

While in Italy investigating a THRUSH plan to divert the Gulf Stream with heavy water, Solo finds himself eluding THRUSH guards, and ends up hiding under the bed of Pia Monteri. Solo escapes a shotgun wedding, the family feels Pia's honor has been compromised, and the girl's American uncles retired Prohibition-era gangsters ""Fingers"" Stilletto, Enzo ""Pretty"" Stilletto, and Federico ""Feet"" Stilletto are called. At the island headquarters of Louis Strago, Illya is tortured by Strago's sadistic female assistant, Miss Diketon. Solo joins forces with the Stilletto brothers to try and rescue him.

Illya goes to the Himalayan country of Chupat to protect the high lama, but is shot by ""Calamity"" Rogers, an American rodeo star. Solo is sent to find Illya, and learns that the prime minister has kidnapped the real successor to the throne and intends to install his own son instead. An entranced girl, Amra Palli tries to kill Solo after being brainwashed by the prime minister.

In Africa, Professor Kenton has developed a superman formula which he has been using on the natives, hoping to build an army with which to conquer all of Africa. Premier Khufu resists the use of the drug on his people. Illya meets up with Harry Blackburn, a shady safari guide, and Marsha Woodhugh, who is searching for her lost sister, a Tarzan like woman named ""Girl"" who has captured Solo.

Solo and Illya must protect Premier Georgi Koz, a Khrushchev like European leader, on a visit to New York, Priscilla Worth is befriended by Loz and she takes him to a school for Santa Clauses run by Francis X. O'Reilly where just one of a series of assassination attempts against him must be thwarted by the two U.N.C.L.E. agents.

Scientist Adrian Cool spots a UFO approaching earth on his radar. His daughter, Coco is kidnapped, and Illya follows and he's captured also. Simon Sparrow, a power-mad millionaire, has faked the approaching UFO to secure power for himself as the representative on earth of the ""aliens"". Sparrow captures Solo and puts him in an experimental wind tunnel to kill him, but he is saved by Corinne. Coco develops a crush on Illya; while they are trying to stop Sparrow, they end up aboard his ""UFO"".

Dr. Rutter, after inventing antimatter, hides out in Suburbia under the name Willoughby because he fears his creation will be used destructively. Solo and Illya take a house there to find him. But THRUSH agent Miss Witherspoon also wants to find Rutter, and when Rutter sends his neighbor Betsy after some rare medicine from the pharmacist, Fletcher, the chase is literally on the find Rutter first.

Solo goes to Sweden to obtain a new suspended animation device from Dr. A.C. Nilson, but the device and its inventor are taken by THRUSH. The doctor's daughter Neila helps Solo find him, and the doctor's assistant, Inga Anderson also feigns cooperation but is actually working for THRUSH agent Heinrich Beckmann. Beckmann uses the device to invade U.N.C.L.E.'s Scandinavian headquarters, and only Solo has a chance to stop him.

Investigating the shipment of a tidal-wave machine by THRUSH, Illya ends up aboard a merchant vessel run by Captain Morton. Morton is obsessed with his past disgrace in a court martial, and the crew is on the verge of a mutiny, which Illya leads just as THRUSH arrives to take possession of the device.

President Nasasos Tunik visits Paris. His assistant, Malanez, is determined to persuade the president that the French are his enemy, and arranges for various embarrassing and insulting incidents to occur. Solo and Illya are assigned to see that the visit goes smoothly, but Tunik falls in love with Candyce, and Malanez plans to disgrace Tunik by framing him in a plot to steal the body of Napoleon from his tomb.

In Greece, Illya tries to recover stolen U.N.C.L.E. documents, but they fall into the hands of Stavros, a Greek bandit, who has ambushed Illya, thinking he is his daughter Kira's convict husband, Manolakas returning from prison. Kita is in love with Nico instead, and Solo and Illya must resolve the love triangle in order to retrieve the documents.

Brothers Simon and Peter Sweet both rival THRUSH leaders vying for promotion, do not realize that the toy hula doll they possess has an extremely powerful new U.N.C.L.E. explosive inside that is activated by heat. As the outside temperature rises, Illya and Solo try to recover it with the help of Wendy Thyme. Solo poses as a representative of THRUSH Central, but Mama Sweet a real member of THRUSH Central appears on the scene.

Jacqueline Midcult writes a best selling novel, The Pieces of Fate, which U.N.C.L.E. recognizes as being based on a series of missing THRUSH diaries. She loses her memory during a THRUSH attempt to kill her, and THRUSH agents Ellipsis Zark and Jody Moore, a book critic, plot to kidnap her and find out where she found the diaries. Solo and Illya take Jacqueline to a small town where her Uncle Charly and Aunt Jessie live, to try and revive her memory, but Zark and Moore follow and they all converge on the attic where the diaries are hidden at the same time.

A dying man carrying a partial film with the secret of Project Quasimodo, a miniature atomic bomb, gives only one clue to finding the rest of the film: the name of Marvin Klump, inept car salesman. THRUSH agents Rodney Backstreet and Beirut capture Klump. Solo and Illya, with the aid of Klump's sister Heather, follow them first to the Alps, them back to the U.S.,where the answer to the puzzle lies in a cemetery.

A THRUSH code is hidden in a dress pattern, and Solo and Illya go to the garment district and encounter the design shop of two down on their luck designers and their model Ramona and the cutter who has a crush on her, Jerry. THRUSH also tries to retrieve the garment, but Ramona keeps forgetting where she left it.

In Rome, American tourist Darlene Sims becomes the unwitting carrier of a perfume atomizer with a secret formula. THRUSH uses a suave ladies man Cesare Guardia to charm Darlene, but he falls in love with her in the process.

Solo and Illya find that THRUSH agent Colonel Picks has developed exploding apples, which will be used to trigger a nuclear stockpile. Nina Lillette, a pretty hillbilly girl, latches onto them for excitement. Illya joins a picking crew at the farm, but he is buried alive in a tunnel with the volatile apples.

Solo and Illya visit the laboratory of Dr. True, who has discovered how to extract gold from seawater. But Dr. True dies from a poison given him by THRUSH agent Randolph, and Randolph also kills his wife Amanda. The gold extraction formula was distributed in portions by True to his daughters, in inscriptions on a photo of himself. Solo and Illya meet Sandy True, who accompanies them to Rome, to find her half sister Margo, now unhappily married to the destitute Baron de Fanzini to London, to find the next sister Imogen, who has been arrested by a Constablefor indecent exposure and finally the Alps, to find Yvonne, who is breaking off an unhappy relationship with Karl Von Kesser. But after decoding the message in Japan, Solo, Illya and Sandy are captured by Randolph and taken to THRUSH central for execution.

Solo and Illya visit the laboratory of Dr. True, who has discovered how to extract gold from seawater. But Dr. True dies from a poison given him by THRUSH agent Randolph, and Randolph also kills his wife Amanda. The gold extraction formula was distributed in portions by True to his daughters, in inscriptions on a photo of himself. Solo and Illya meet Sandy True, who accompanies them to Rome, to find her half sister Margo, now unhappily married to the destitute Baron de Fanzini to London, to find the next sister Imogen, who has been arrested by a Constablefor indecent exposure and finally the Alps, to find Yvonne, who is breaking off an unhappy relationship with Karl Von Kesser. But after decoding the message in Japan, Solo, Illya and Sandy are captured by Randolph and taken to THRUSH central for execution.

Solo and Illya are responsible for the security during Waverly's upcoming address to his alma mater, but the campus is seething with protest. Illya joins the demonstrators, and meets Minerva Swight, the daughter of the dean. The head of the board of regents, Jonathan Trumble, is a THRUSH agent, and he hires campus agitator Gregory Haymish to try and kill Solo and Illya, while Trumbull's THRUSH superior, Number 24, undergoes plastic surgery so he can impersonate the dean during the ceremony and kill Waverly himself.

Alexander (Rip Torn) a megalomaniac industrialist, plans to conquer the world like his namesake, Alexander the Great by breaking each of the ten commandments along the way. he has his henchman Parvix (David Sheiner) steal the army's ""will gas"" to help him do so, and Solo investigates. Solo encounters Tracey Alexander (Dorothy Provine), Alexander's ex-wife, who wants to tag along with Solo to get the money Alexander owes her. The trail leads Solo, Illya, and Tracey to a posh party at Alexander's, where Solo defeats him in a human chess game; to a tomb, where Alexander and his aide Dr. Kavon (David Opatoshu) leave Solo tied under a descending scimitar while Illya and Tracey are hanging over a bottomless pit with a candle burning their rope; To Alexander's farm in Virginia, where Illya is nearly cut in two by various farm implements.

Alexander (Rip Torn) a megalomaniac industrialist, plans to conquer the world like his namesake, Alexander the Great by breaking each of the ten commandments along the way. he has his henchman Parvix (David Sheiner) steal the army's ""will gas"" to help him do so, and Solo investigates. Solo encounters Tracey Alexander (Dorothy Provine), Alexander's ex-wife, who wants to tag along with Solo to get the money Alexander owes her. The trail leads Solo, Illya, and Tracey to a posh party at Alexander's, where Solo defeats him in a human chess game; to a tomb, where Alexander and his aide Dr. Kavon (David Opatoshu) leave Solo tied under a descending scimitar while Illya and Tracey are hanging over a bottomless pit with a candle burning their rope; To Alexander's farm in Virginia, where Illya is nearly cut in two by various farm implements.

Illya Kuryakin infiltrates a South American prison camp where Thrush are storing the 'Ultimate Computer'.

U.N.C.L.E. and Thrush agents compete to gain possession of a mind-reading device created by a magician who has been murdered by Thrush.

Napoleon Solo is given the job of searching for Thrush security records.

The 'Re-collectors' claim to be trying to locate works of art stolen by the Nazi's but all is not as it appears.

Illya goes to find Thrush's vaporizing machine, but is captured by Sophie, the headstrong daughter of the local tribal chief, Sulador. in New York Solo convinces retiring THRUSH agent David Lewin that THRUSH intends to kill him, and elicits his help. Lewin and Solo are taken to the base in the desert, just as Illya leads the band of nomads, whose confidence he has gained, in an attack on the base.

Solo and Illya go to India to help Suzanne de Serre, a French botanist trying to find out why the jungle is dying and local natives are disappearing. Prince Panat and Drusilla Davina, along with Colonel Quillon, are systematically using a chemical to destroy the jungle and kidnapping natives to work in the jewel mines for the prince.

THRUSH is so eager to get their hands on a boy genius that they murder the boy's father. But then they have to deal with the boy's madcap aunt.

THRUSH eastern in Japan acquires a volcano-activating device, and Solo and Illya, along with Cricket Okasada, a film student, infiltrate a toy store and a karate school to find it. THRUSH leader Mr. Kutuzov oversees local THRUSH head Harada in the operation, and Solo finds himself fighting for his life against a life size sword wielding puppet.

French fanatic Robespierre seeks to destroy France's vineyards in his quest for virtue, and Solo enlists the aid of scientist Raoul Dubois and his daughter Albert in combating the plan. Illya is captured by THRUSH agent Carl Voegler and, with a target painted on his back, is hunted through the woods by Voegler's archers.

A top-level U.N.C.L.E. conference is to be held in Switzerland, but a nearby boys' school is actually a THRUSH front run by Mother Fear and Dennis Jenks that is training its students to be assassins. Solo is captured by the boys, and, when he refuses to reveal the conference location, is forced to operate the controls of two electric trains so they do not collide with each carrying a vial of deadly nerve gas. Illya and Anna Paola, a social worker who resent children, are also captured. The escape, and arrive at the conference just as the boy's choir is ready to kill Waverly and the others with THRUSH rifles from under their robes.

Solo and Illya board the Adriatic Express train on New Year's Eve to intercept Madame Nemirovitch, a THRUSH agent who is carrying a chemical that is capable of stopping the reproductive process. Eva, a young girl who delivers a message to Madame Nemirovitch as the train leaves, is caught on board. Throughout the evening, the THRUSH agent and Solo and Illya engage in a battle of wits as the train speeds along its route.

Squire G. Emory Partridge returns, having acquired in Alaska a large quantity of Quadrillenium X, a very heavy metal with high magnetic powers which THRUSH wants to use to disrupt world communications. Solo and Illya are nearly killed by the local Eskimos, but are saved by the chief's daughter, Murphy. Partridge and his niece Victoria capture them, but they escape only to end up in a tavern brawl.

Solo and Illya travel to the Caribbean to help Dr. Delgado, who is under a voodoo curse and in a zombielike trance thanks to the local dictator, El Supremo, and his chief of police, Captain Ramirez. The U.N.C.L.E. agents are assisted by Suzy, an American hairdresser whom El Supremo will not let leave the island. They eventually turn to voodoo queen Mama Lou to turn the tables on him.

THRUSH agent Harry Pendleton is captured and commits ""suicide"" with a reversible chemical, but his superior, Simon Baldinado, refuses to revive him because he is attracted to Pendleton's girlfriend, Jojo Tyler, Solo gets Jojo to help U.N.C.L.E. retrieve the ion projection machine Baldinado has hidden at the mortuary front for THRUSH by feigning affection for Baldinado, who allows his personal plans for Jojo to affect his judgment.

Solo and Illya travel to Circe to intercept a drone plane carrying a load of THRUSH cash. There, they encounter THRUSH agent Colonel Hubris, as well as two local girls who are looking for husbands.

THRUSH has developed with the aid of Dr. Elias Swan, a strain of minute, deadly bees. THRUSH agent Mr. Mozart captures Illya and Tavia Sandor and uses a high-frequency sound machine that threatens to shatter their eardrums to force Illya to take him to U.N.C.L.E. headquarters so he can release the bees. Illya does so, but Mozart is intercepted, and in a battle on a rooftop Mozart is shot and the bees get loose.

When secret ""File 40"" documents turn up outside headquarters, Waverly assigns Solo and Illya to find out if George Donnell is a double agent. Carla Drosten is too anxious to accuse Donnell and Solo must use special ""Waverly rings"" to try and expose the real double agent.

Illya investigates the mysterious disappearance of cats in Soho, and he and Solo discover that a salon run by Madame De Sala is a front for her plan to develop a rejuvenation process, which De Sala plans to use on the now elderly target of her romantic desires, Sir Norman Swickert. Assisted by Joanna Sweet, a nurse, they end up in the bottom of a wine press. Meanwhile, THRUSH agent Jordin plots to obtain the process for THRUSH.

Illya investigates the mysterious disappearance of cats in Soho, and he and Solo discover that a salon run by Madame De Sala is a front for her plan to develop a rejuvenation process, which De Sala plans to use on the now elderly target of her romantic desires, Sir Norman Swickert. Assisted by Joanna Sweet, a nurse, they end up in the bottom of a wine press. Meanwhile, THRUSH agent Jordin plots to obtain the process for THRUSH.

Illya parachutes out of a plane carrying THRUSH code documents, but lands in the desert at an abandoned Foreign Legion post run by Captain Basil Calhoun (Howard Da Silva). Illya is accompanied by a stewardess, Barbara (Danielle DeMetz) while Solo races to find them before THRUSH does.

While investigating a THRUSH plot to sabotage space shots, Solo and Illya are incapacitated by a quartzite radiation projector. Waverly assigns new trainee April Dancer along with over the age of retirement agent Mark Slateto find the antidote and destroy the plan. April infiltrates the cosmetics company of THRUSH agent Arthur Caresse as a model, but she is uncovered by Caresse's sister Jean.

Solo, while searching for a secret map in Nevada, swallows an amnesia capsule just before being captured. THRUSH agents Arum Tertunian and Longolius try to revive his memory with a seductive female agent, Mara, while Illya races to find him before he starts to remember.

Solo and Illya discover that the world diamond market is being affected by a gang of English criminals headed by Blodgett, who smuggle diamonds inside pudding sold unwittingly by Victoria Poque. They enlist the aid of a master diamond thief, Rafael Delgado. Solo and Victoria end up in Brazil, with Solo tied to the front of a cannon and about to be executed.

THRUSH agent Elom tries to kidnap a geologist who has developed an earthquake activating machine, but mistakes debt-ridden salesman Buzz Conway for the scientist. Solo and Illya let THRUSH go on thinking Conway is the scientist, while Elom lets his attraction for THRUSH agent Narcissus Darling interfere with his judgment. Conway is captured, and Solo and Illya must rescue him and find the machine.

Lucho Nostra and a group of criminals take over a tiny European country, Ingolstein, because it has no extradition treaty. Prince Frederick is afraid to kick them out, so Solo convinces princess Vicky to return and do so, only to find that she cannot because the treasury has been replaced with IOU's to Nostra for the prince's gambling debts. Nostra arranges for permanent protection by forcing a marriage between Vicky and one of his henchmen, Artie King, but the two actually do fall in love. King duels Nostra, with the fate of the country riding on the outcome.

Solo uses hillbilly clairvoyant Clemency McGill to counter the efforts of Count Zark, a vampirish THRUSH agent who plans to use radioactive bats to jam the world's radar systems from his castle. Solo and Clemency make their way to the castle with Illya, but Zark manages to release the bats.

Solo and Illya try to protect Professor Lillian Stemmler from THRUSH after she invents a drug called Plus X, which heightens all the human senses. Unbeknownst to them, she is a THRUSH agent herself who at first cooperates willingly, then has second thoughts. But THRUSH agent Rollo kidnaps her daughter Leslie and forces her to cooperate. The drug is given to three THRUSH agents who will attack a U.S. government plutonium plant using their superior senses, while at the same time the guards will be given a dose of Minus X, which dulls the senses.

THRUSH agent L.C. Carson uses an Indian reservation as a front for his plan to assemble a hydrogen bomb, and kidnaps the tribe's chief, High Cloud, to ensure cooperation. Solo arranges for the Chief's daughter Charisma to return, but she ends up being kidnapped along with Solo and Illya, who is disguised as an Indian. Solo and Illya, along with a band of young Indian warriors on Motorcycles, encircle Carson and his men and try to stop them before its too late.

After a THRUSH attempt to kill Waverly is thwarted, Solo is assigned to prevent the assassination of a visiting African premier (William Marshall) at the hands of Andrew Vulcan (Fritz Weaver), and with the help of a housewife (Patricia Crowley) he learns that the premier himself is allied with THRUSH and plans to kill his two top aides (Ivan Dixon and Rupert Crosse) in a fake accident.

Solo investigates the curious death of an air force man in Iowa with scuba gear, and with the help of Jill Denison (Katherine Crawford) uncovers a plan by Clint Spinner (Slim Pickens) to steal a missile- plane from a secret base under a farm.

In Yugoslavia, Solo and Illya are aided by Marion Raven (Jill Ireland) in stopping Gervaise Ravel (Anne Francis) and her partners from using a fear gas to overthrow various governments. While two of them are captured, two of them escape, and the story continues in "The Giuoco Piano Affair"

Solo and Illya investigate a series of kidnappings that lead to a modern-day pirate ship run by Captain Shark (Robert Culp), who is filling his Noah's Ark with craftsmen from all walks of life to repopulate the world after the nuclear holocaust he feels is imminent. With the help of Harry Barnman (Herbert Anderson) and his wife Elsa (Sue Anne Langdon). Solo and Illya pose as shipwrecked sailors to in turn wreck his plans.

When a rare postage stamp at an auction reveals that a former SS scientist, Professor Amadeus, is still alive and experimenting with the secret of "suspended animation," Solo and Illya enlist the aid of college students Terry Brent (Brook Bundy) and Chuck Boskirk (Burt Brinckerhoff) to beat THRUSH agent Angelique (Janine Gray) to Amadeus's lab, where Solo is captured so his blood can be used to revive the suspended body of the Fuhrer.

In the Yucatan, THRUSH agent Walter Brach (Carroll O'Connor) brainwashes important people from many nations to be "time bombs" who will return to their jobs and do THRUSH's bidding. After eluding Brach's henchmen Chuke (Shuji J. Nozawa) and his leopards, Solo and housewife Chris Linnel (Joan O'Brien) enlist the aid of Mrs. Karda (Dovima), Brach's numerologist, to help them escape.

The conuation of "The Quadripartite Affair". Gervaise Ravel (Anne Francis) returns and Solo and Illya again enlist Marion Raven (Jill Ireland) to help them pursue her through the Andes, where the treachery of police lieutenant Manuera (James Frawley) impedes their efforts to capture Ravel.

THRUSH creates a double for Solo, and with the seductive aid of Serena (Senta Berger), Darius Two (Michael Evans) kidnaps Solo and substitutes the phony into U.N.C.L.E.'s efforts to transport the code to a secret new weapon. Illya and stewardess Sandy Wister (Sharon Farrell) eventually realize a switch has been made, and the real Solo escapes and in a climactic scene battles "himself".

Solo and Illya devise a clever scheme to discredit a Balkan intelligence chief (Werner Klemperer) with a bogus secret gas. With the help of a bankrupt exterminator (William Shatner) and his wife, Illya poses as a fellow countryman and exploits the paranoia of the chief and his bumbling assistant (Leonard Nimoy).

Solo gets an unwelcome young companion (Kurt Russell), a ten year old who wants Solo to marry his widowed mother, in his efforts to find the source of a deadly chemical that killed an entire Scottish village. In a race to find the source with General Yokura (Leonard Strong), Solo eventually uses a ring on the finger of a statue to pinpoint a cave where the deadly chemical has leaked from, but has to use his wits to escape when he is trapped there by Yokura and his men.

A rocket launch which releases a damaging spore into the Soviet grain belt is traced back to the US. Illya Kuryakin is made to return home to Russia, who threaten to retaliate, so Napoleon Solo is forced to search alone for the group of scientists who are trying to start World War III.

When a minor European leader is assassinated, Solo steals a medallion from his body containing a microdot listing the THRUSH agents in the country, but must elude the secret police and outwit intelligence agent Satine (Ricardo Montalban), who also wants the medal. Teacher and tour guide Sara Taub (June Lockhart) and her high school students are used by Solo to try and sneak the medal over the border.

Solo and Illya investigate the disappearance of several crime figures, and the trail leads to Fasik el Pasad (Paul Stevens), a deposed ruler who is building an army of criminals to regain power. Solo poses as a black-market arms dealer and infiltrates the operation, but is hampered by well-meaning Ernestine Pepper (Diana Millay), a notary public trying to find one of Fasik's men, Angel Galley (Jan Melin).

On vacation Solo is asked by an old love interest, Clara Valdar (Madlyn Rhue) to help her smuggle Gypsy leader Emil (Jacques Aubuchon) out of Terbuf with evidence that the corrupt head of the secret police, Colonel Morisco (Alan Caillou), has been embezzling foreign aid money with the aid of the repulsive Major Vicek (Albert Paulsen).

U.N.C.L.E. must transport captured THRUSH official Egon Stryker (Ralph Taeger) from New York to Washington with THRUSH rescuing him. While Waverly takes a decoy along one route, Solo and Illya take the real Stryker. Or is it ? But in a mixup, Fran Parsons (Joanna Moore),a secretary on her lunch hour, gets handcuffed to Stryker and has to go along.

THRUSH agent Anton Korbel (Ken Murray) guards THRUSH's fifty-million dollar treasury in a vault beneath his casino, and Solo and Illya recruit a naive girl from Minneapolis, Susan Callaway (Marlyn Mason), and shady safecracker Marcel Rudoph (Dan O'Herlihy) to break in and destroy the cash.

Solo goes to India to investigate the death of a fellow U.N.C.L.E. agent in an airline crash, and discovers that a cult of Thuggees headed by a maharajah (Murray Matheson) is causing the crashes in order to loot the passengers. But Solo and THRUSH agent Tom Simpson (Linden Chiles) are looking to recover one item in particular - U.N.C.L.E.'s new polygraph device.

Prior to an important conference at U.N.C.L.E. headquarters, a bizarre series of events occurs revolving around a strange man Mr. Hemmingway (Richard Haydn) who keeps appearing and disappearing at will in the building. Solo and Illya learn that he has been placed there by Waverly to test the security system, but THRUSH also has an inside agent, Riley (Peter Haskell), who plants an exploding false tabletop on the conference table at the direction of Dr. Egret (Lee Meriwether). Solo has only a few minutes, before the conference is to begin, to try and find out who the infiltrator is.

Solo and Illya agree to help Major Morgan (Gene Raymond), Solo's old commanding officer, steal a national symbol sceptre for his people from a dictator. Morgan is killed and Solo and Illya and Zia (Ziva Rodann), Morgan's female aide, are captured and sentenced to death. After they escape, they find that Morgan is still alive and has duped them into stealing the sceptre for him because of the precious gems it contains.

Waverly's cousin is killed by his own dog when he refuses to sell his stock to a gypsy named Delgrovia (Paul Lambert), so Illya investigates and, with the help of Ursula (Susan Oliver) and dog expert Guido Panzini (Pat Harrington Jr.), traces two of the dogs to Delgrovia's estate, where he and Ursula are soon cornered by a pack of deadly Doberman pinschers.

Solo and Illya protect a young Himalayan prince (Michel Petit) and his nurse (Susan Seaforth) from THRUSH agents who want to kidnap him one of whom turns out to be his bodyguard.

Solo uses the former girlfriend (Kathryn Hays) of 2 brothers, Joseph and Max Van Schreetan (Gerald Mohr, Lloyd Bochner), to thwart their plan to control the diamond market, while at the same time THRUSH agent Corio (Alfred Ryder) tries to steal their cache of gems.

Waverly is poisoned, and taken to a hospital where he is subjected to the rays of a brain-altering machine by THRUSH agent Dr, Dabree (Elsa Lanchester) designed to make him ineffective without killing him. While investigating others who have suffered the same fate, Solo finds Cecille Bergstrom (Yvonne Craig) and together they try to unravel the mystery and save Waverly.

Solo is aided by tourist Bernie Oren (Glenn Corbett) in finding a black market auction in Hong Kong run by Mr. Cleveland (Gavin McLeod) that sells military secrets, including a microfilm in a rare coin. Oren is infatuated with Heavenly Cortello (Karen Sharpe), and hinders more than he helps Solo, while Illya tries to infiltrate the auction disguised as a Mongolian warlord.

U.N.C.L.E. Portuguese translator Mandy Stevenson (Barbara Feldon) hungers for more excitement, so Solo sends her on a fake mission to get Waverly's tobacco not realizing she has taken an important microfilm that THRUSH is after. Solo, Illya and THRUSH pursue her through the streets of Manhattan, and eventually she and Solo are captured by the THRUSH leader, Victor Gervais (Cesar Romero), and Solo has to use his skills as a marksman to escape.

Solo attends a revival meeting conducted by evangelist Brother Love (Eddie Albert), who is actually a THRUSH leader constructing a nuclear spaceship with the aid of a kidnapped scientist, Dr. Hradny (Robert H. Harris). College student Pearl Rolfe (Maggie Pierce) is kidnapped by Love's followers, and Solo must rescue both victims and destroy Love's plan at the same time.

Squire G. Emory Partridge (George Sanders) kidnaps Illya and lures Solo to his manor in order to kill them off in his dungeon torture chamber in revenge for a past encounter. But Peggy Durance (Bonnie Franklin) helps them escape, with the unintended aid of Partridge's bumbling wife Edith (Jeanette Nolan).

Solo and Illya travel to the Riveria, where they search for a serum that supposedly provides great strength and even brings the dead back to life. There they meet Madame Streigau (Marian Moses), who is actually Dr. Egret of THRUSH, as well as Lucia Nazarone (Danica d'Hondt) and her bevy of beautiful blonde helpers. With the help of teacher Lavina Brown (Kipp Hamilton), they trick Mazarone into thinking they have the serum also, and become the targets of her "superwomen".

Retired U.N.C.L.E. agent Albert Sully (Martin Balsam) is brought back to impersonate a crime syndicate leader, and insists on leaving Solo and Illya behind and running the operation himself. He reunites with wartime fellow agent and old flame Bryn Watson (Barbara Shelly) and tracks down a secret crime conference, with the exasperated Solo and Illya trying to keep him from being killed in the process.

Unaired color pilot episode which MGM used to sell the series to NBC. The plot was reworked and became the subsequent black & white episode The Vulcan Affair. This was included as a bonus track in the 41 DVD set, The Man from U.N.C.L.E - Complete Series.