Johnny and Connie didn't see how a few beers at a cool party could lead them on a collision course with full blown multi-drug addiction. But it did. Soon they found themselves fully in The Game and The Life - which meant they were on the road to death and destruction. They finally realize they had been playing poker with the devil and gambling with their lives. But can they stop taking that "one last hit" over and over again, before he calls their bluff? Do they hold a trump card? This episode is only the beginning.

Ruthie still parties as hard as she did when she was a teenager. Problem is, her daughter Isabella is only 11 years old and is often left with the task of taking care of her younger brother and sister - sometimes for days. With extended family help and under the watchful eyes and prayers of a good neighbor, Izzy does her best. But is it good enough? What made her Mama become this irresponsible in the first place, and how does she begin to make a change?

Sergio grew up in the 'hood. He's mostly been down for his vatos all his life, and they want him to fully join them. But as he reaches manhood, Sergio's not so sure anymore. Because Sergio is also a genius, with many opportunities awaiting him in the outside world. But he must make a choice. Angel is a little older, a former cholo from the block, and he has become a Christian. Angel's cousin Rico is still deep in "The Game." There are choices and mysteries to uncover as these men, and their mothers, aunts and friends argue and laugh about what is most in important in life.

Though just emerging from her teens, Cherry is an experienced and drug-addicted prostitute. Her only friends are her homegirls, Sinthia and LaVita. Though cold and wary, she still had dreams of another life and a better place. When Trish - a former hardcore prostitute and friend - shows up on the set, Cherry is invited to a better life and a better place - even better than those in her happiest dreams. The decision is hers to make... or is it? Pimp Tommy and Madame Lisa have other plans.

Mrs. Price is a sold-out drunk. Two of her children have grown up and moved far away, and young Linda has been left mostly alone to deal with her extremely irrational mom. Together they plan an intervention, and a dramatic and startling confrontation with Mom ensues. They plan to help Mrs. Price change, but she has another plan altogether...

As a drug dealer and baller in his hood, Ticket had it made - or so he thought. Then he found out that the money, cars, and hype don't really mean a thing, especially when you're in a near coma after gettin' shot up by your "associates." Almost dead and confined with Mr. Edwards - an older businessman who is enduring a similar fate, Ticket gets help from unexpected sources - and gets schooled in the process. He receives truths that could really save his life.