Four patients with serious illness arrive at the NIH's Building 10 to enter potentially groundbreaking clinical trials, resting their hopes for a cure on the brilliant minds that work there.

While Bo Cooper recovers from a near-death experience, Anita McAlister weighs her treatment options. Patients Lucy Wiese and Deidra Williams receive highly experimental bone marrow transplants.

All four patients meet with their doctors one last time to learn whether their experimental treatments were successful, and what the future holds for them.