Roger has enormous growths on his nose that drip pus, attract flies, and are so large that he can barely breathe; Sandra and Jessie are sisters who bonded over their many undiagnosed face bumps.

Roger returns with his gigantic nose growths in the hopes that Dr. Lee and her colleagues can help before it's too late. Christine has lost her essence due to a large growth on her shoulder. Tiffany has a recurring cyst on her eyelid.

Brittany has been called a monster due to her genetic condition that causes head-to-toe bumps. Leonardo has a fist-size growth on his head, but he is terrified of doctors. Tamyra has skin so thick that she shaves the bottom of her feet for relief.

Monica returns for a second time in the hopes that Dr. Lee can remove some more of her face growths. Ken has several large cysts on his head that he has tried to remove on his own. Maranda has a mystery skin sore that causes her discomfort.

Corey is a drag queen and has a bump dangling from his booty; Adam has a semi-circle of about a dozen cysts on his head that he covers with a hat; Virginia has large growths on both of her upper arms that make it difficult to travel in her RV.

Keke is covered in bumps that make her embarrassed to be intimate with her husband. Jim is a widower with two lumps who wants them removed for himself and his late wife. Corey has been labelled a devil worshipper because of his forehead growth.

Stacey's shoulder growth prevents her from being the playful teacher she once was. Matthew worries that his mysterious shin rash may be dangerous. Both need Dr Pimple Popper's help to fix their skin.

Lattyse was born with a mysterious growth above her eyebrow that gives her headaches; Robert has a tomato-sized growth on his butt cheek that causes him pain and discomfort; Sharon has an embarrassing, stinky, squirting cyst under her breast.

Terry's nose growth has prevented him from meeting his grandkids; Remi has alligator-like skin and is not used to taking care of herself; Austin has an embarrassing birthmark right next to his eyelid; Mary Jo has a throbbing bump on her neck.

Jaclyn has a lump on the back of her head that causes her emotional distress. Shane has a growth between his eyes that could put him in danger at his electrician job. Brittany has seen multiple doctors about the sores on her body with no answers.

With pandemic safety protocols in place, Dr. Lee reopens her office. Monica has a large birthmark growing on the side of her face. Jackie has a melon-sized lump on the back of her shoulder. Reginald has large, rare growths on the back of his head.

Dr. Lee tries to provide the help Reginald needs in order to remove two large rare growths on the back of his head; Che'Re has a prominent bump on her face that has put her in a dark place; and Juan has several painful boils on the back of his neck.

Dennis has several giant growths on the back of his head. Juan has a rare condition he hopes Dr. Lee will understand. Natalie searches for answers as to why her body is covered in hundreds of mysterious dark bumps.

Audrey pops the painful bumps that cover her body so she can feel relief. Felicia has a peculiar looking dark growth on her forehead. Krista's excessive sweating is so severe that on any given day she could fill up an entire milk jug with her sweat.

John fears the large lump on his neck could become so big that it may eventually suffocate him. Shoshana is depressed because of the big growth on her forehead. Ashley hopes Dr. Lee can provide some relief from her three painful skin conditions.

Yaellie, a sweet 9-year-old, has itchy psoriasis on over 90 percent of her body. Matt, a former Marine, has a large recurring lump in his armpit. Twins Tracie and Stacie have numerous matching bumps on their heads that sometimes leak.

Joanne has been held back from success because of her forehead growth; Shakisaha split her left earlobe after stretching it with gauges; Mike is a tough guy with a soft bump on his head; Dania's rhinophyma has kept her from enjoying her life.

James has a large, squishy lump on his forehead; Tanisha has a growth on her arm and itchy scars all over her body; Ed wants his stomach lump removed before his girlfriend gets out of prison; Justin has painful mystery bumps all over his head.

JD is a gentle giant with a pear-shaped mass hanging off of his ear; David has two bumps on his neck and one on his finger that give him pain; Julie hopes Dr. Lee can remove her large back growth so she can return to the sea.

Stephen's large, bulbous nose gets him unwanted attention, and he hopes Dr. Lee can help; Veronica wants to be free of secrets, including the bump on her butt; Marty has a large, 30-year-old growth on his shoulder that he is ready to remove himself.

Tim has a massive growth on his back that affects his ability to work and socialize. Daniel has debilitating psoriasis that covers 90% of his body. Gloriana and Yolanda are a mother/daughter duo who have bonded over their bumps.

Traci's confidence has been destroyed after years of bullying from the bumps on her face; Ravon has a unique dangling growth on his leg; David has a large lump.

David is back to see Dr. Lee after she spotted a suspicious growth under his eye. Nicole is depressed because of the bumps all over her neck. Steve has a noticeable lump on his forehead. Allen has a growth on his bicep but is terrified of doctors.

Inoke has a huge, possibly life-threatening bulge on his shoulder; Delano returns with his back lump after Dr. Lee removed a liter of fluid from it; Reed has hundreds of bumps on his chest that burst and leave nasty scars.

Tony has large growths on his nose that impair his breathing. Kevin has a bump in his jawline that is a "lady deterrent." Marie has an unsightly lump on her forehead that makes her a hermit. Tommy's leg bump makes it difficult for him to work.

Tim has a massive growth on his back that affects his ability to work and socialize. Daniel has debilitating psoriasis that covers 90% of his body. Gloriana and Yolanda are a mother/daughter duo who have bonded over their bumps.

Jen has substantial growths on her ears that cause her depression, pain, and vertigo. Juliet is under emotional distress because of the bumps all over her neck and chest. Gerald has a mysterious, kiwi-size lump on his middle finger.

Gerald is back to see Dr. Lee and a hand specialist about a huge, intrusive bump on his middle finger; Vinnie has a large, embarrassing birthmark on his neck; Leta has a lump on the back of her thigh that she has been hiding from her fiancée.

Rhonda has bumps all over her head, including a horned growth that has her deeply concerned; Fred has a mysterious condition on his hands and has not been able to get answers from any doctors; Kevin has a huge lump protruding from his hip.

Dr. Sandra Lee treats Heather, who has a huge growth on her leg and fears removing it could leave a keloid scar; Paul has a giant hump on his back.

With Bonus Footage - Genner has flown all the way from The Philippines to have Dr Lee help with his bumpy nose. Chris suffers from Psoriasis. April is covered in bumps that have disfigured her arms.

Gerard has nearly a hundred lumps varying in size all over his body; Gina has bloody lesions all over; Eric has a large bump on his head that he calls his on and off button.

April is covered in bumps that have disfigured her arms; Genner has flown all the way from the Philippines to have Dr. Lee help with his bumpy nose; Chris suffers from psoriasis that nearly covers his body and a bump on his head.

Matt has a skin condition that causes tumors to grow all over his body; Yamileth hasn't pursued her dreams because of the lump on her neck; Pat is covered with dark spots from her neck to her abdomen; Jennifer has a unicorn bump on her forehead

Louis is a veteran who is covered in scaly, dry skin that makes him feel like an alligator; Irais's kids are bullied because of the embarrassing growth on her head; Johnny has been living with a stubborn lump on his back for too long.

Amber has hundreds of tumors on her face; Antonio has a mound on his spine and is afraid it might be impossible to remove; sisters Cheri and Janice both suffer from possibly matching lumps; Tatiana has an embarrassing bump on her butt cheek.

Patrick's nose is covered by huge bumps, and he can barely breathe; Aziza and Lauren are friends who bonded over their matching wrist lumps; Joe has a mound in the middle of his forehead that looks like a third eye.

Lisa has a horn growing out of the back of her head and fears that it could be cancer; Victor has a bulbous lump on his chest; Chuck has a Popeye-shaped bump on his arm; Christian and Jonathan are teenage brothers with matching lumps.

Taylore is a beautiful young woman who has unsightly elf-like bumps on her ears; Jose never goes out because of the baseball-sized lump on his head; Ken is covered in painful bumps that make it difficult to do everyday things.

Barbara's back lump became more noticeable after she lost 131 pounds; Bob has two painful bumps on his back; Hilda's depression is a result of the multitude of bumps on her eyelids; Art has one big bump on his head that he covers up with hats.

Josh has a large knot on his head resulting from a car crash from 18 years ago; Brittney is covered in mysterious bumps; TJ has a hard, curious lump protruding from his side; Luis has a bump on his shoulder and his daughters fear it's dangerous.

Leonard has an alarming bump hanging off of his arm that looks like it's breaking through the skin; Brandon has several lumps on his head that make him fearful for his life; Jess gets a noticeable lump on her butt after falling down the stairs.

Melissa has tried to cover a huge lipoma with a sweatshirt for years; Tyler's fear of cancer has kept him from having his huge head lumps diagnosed; Tahj is covered in painful boils; Amber has ear keloids that have taken control of her life.

Ronen's mysterious lump above his knee is one of the largest Dr. Lee has ever seen; Amber suffers from a debilitating skin disease that no one understands; Sandy has a neck lump she calls Tommy; Kristy's eyelid cyst is ruining her life.

Half of Mary's body is a size 18 while the other is an 8; Anthony's cyst is in the area called the Triangle of Death; Shane wants to get a lump off his back; Brandi's anxiety may keep her from getting a lump removed from her chest.

Diane has thousands of tumors all over her body that have ruined her life. Will fears his shoulder lump will be ripped open at work. Anthony's daughters force him to get his lump examined; and Kal Elle detests her hideous varicose veins.

Belinda's lump on her neck causes her to basically be immobile; Nicole won't get married until she gets her arm pit lump removed; Adela's chest and back are covered in wisdom spots; Nick foolishly removed a lipoma at home and now needs Dr. Lee's help.

Taylor has a large bump at the base of her spine that is far more dangerous than she realizes. John jokes about hip lump, but turns out it's no laughing matter. Noelle had her ears stretched as a teenager, but now wants them repaired.

Dr. Sandra Lee is a renowned dermatological surgeon who is tasked with removing life-altering growths from her patients' skin so they can try to reclaim their lives.

Dr. Popper demonstrates her favorite types of pops and changes the lives of patients in desperate need of a good pop.

Dr. Lee and her staff fa-la-la-la-POP their way through the day.

The holidays are here, and Dr. Lee and her staff are swamped once again before Christmas. This time, however, Dr. Lee is not her normal, chipper self. Bah. Humbug. The spirit of Christmas is all around her, but she struggles to find it within herself.