After being diagnosed with a degenerative neurological disorder, Chicago Mayor Tom Kane must set aside his personal issues as he attempts to run the city with an iron fist, while also dealing with the upcoming gubernatorial primary.

With a new, powerful entry in the race, Kane and his people flex their political muscles to maintain their hold. Meanwhile, a worried Meredith suspects her husband is keeping something from her.

With Zajac's campaign gathering steam, Kane needs to adjust to his health situation; Miller digs deep to come up with some embarrassing dirt on Gov. Cullen.

Kane finds himself starting to lose control, both politically and personally, as his supporters begin to question their confidence in him. Zajac ventures into uncharted territory while campaigning as Miller continues to dig for answers.

After long-buried information resurfaces, Kane and his camp find themselves battling the media for control of public perception. With the primary just around the corner, they'll have to pull out all the stops to contain the situation and keep the upper hand.

Kane takes an unannounced break from City Hall as his political image hits an all-time low. The election looms and he'll need to enlist the help of others to weather this storm. Kitty, at an emotional impasse, makes a bold move while Meredith, increasingly suspect of Kane's behavior, seeks opportunities of her own.

Just days away from the election, Kane slowly regains control over City Hall. Though a swift political move will help identify his adversaries, will doing the unthinkable improve his public image in time?

Election Day. The race is close, and while the candidates campaign, Kane and Stone must do their part to turn the gears of the political machine. Emma's world is turned upside-down while Meredith must go to great lengths to prove her allegiance to Kane.

Featurette with Kelsey Grammer and Farhad Safinia.

When Kelsey Grammer appeared on “Conan” recently, he slipped in a joke about sex that his ex-wife doesn’t find funny at all. It began as Grammer defending his new wife’s honor after reading several blurbs about how they’d met–some online commenters were asserting that the two had a one-night-stand that blossomed into something more–and wanting to clear the air. “I did want to clear this up…it said something about how Kate and I had met and hooked up in London and that she’d spent the night with me, you know, a one-nighter. That’s not true. We kissed that night….we didn’t do much more than kiss, actually, for several months.” “I would think that would be difficult,” Conan said. “You meet someone, there’s obviously passion there…” “Oh, for a guy who hadn’t had sex for a decade it wasn’t that hard,” Grammer said with a laugh.