Cathy continues to lie in a coma after being run over by Niall Boylan unaware that she lost her cherished baby girl - Rachel - in the accident. Liam's son Ian is in trouble yet again and gets expelled from school and Liam has no choice but to put him into a fee paying school. Daisy returns home with Conor to be at Cathy's bedside and is there when Cathy suffers a brain haemorrhage and dies.

Dan's grief over Cathy's death is overshadowed by hearing that Niall Boylan will escape relatively free from a serious conviction. Dan's solicitor warns Dan to stay away from Niall. Meanwhile, new locum Dr Grace Sefate makes an impact on her first day when her belongings turn up before her. This unusual entrance immediately gives Grace an air of intrigue but she immediately asserts herself as a capable and dedicated doctor. Lorcan starts to struggle with his illness, now that he is on a harsh course of anti-retroviral medication for his HIV and this sees him becoming ...

St. Matthew's Hospital Director Michael Kinsella is keen for Julia to take over the job but she declines and tells him she is happy at the Clarence Street Clinic but will she regret her decision when long standing patient of hers Elayne Sheridan discovers she is pregnant for the fourth time and places Julia in an unenviable dilemma. Meanwhiile, Dan continues his thirst for revenge on Niall Boylan through his wife, Aideen and discovers her love of art. Clodagh agrees to help out on the night clinic and the methadone bus and is moved by Lorcan's dedication to his ...

Grace tells Ruairi about her missing sister Jasmine when he finds one of her flyer's on the photocopier. Lorcan asks Dr Kent about getting involved with someone given his HIV status. Keelin notices that a young client's fitness levels have gone through the roof and later he suffers a heart attack brought on by his use of illegal steroids. Ian and Liam agree a truce but Liam's dependence on Rocusin tablets makes him jump to incorrect conclusions about Ian later after he sees Ian's old buddies Phil and Martin outside their house.

Ronan and Keelin's lives are turned upside down when a senseless attack on Ronan by one of Ian's friends leaves him potentially paralysed. Meanwhile, Liam's addiction begins to get worse and cracks begin to appear in Daisy and Conor's relationship as Daisy struggles to juggle her work with her home life. Elsewhere, Cara struggles with what she did to Hope and Kieran.

Liam continues taking Rocusin, and even steals a prescription from one of Grace's patients. After giving wrong medication to another patient, Liam blames Grace and convinces the patient to back up his story. Julia takes Liam's side in the matter. It takes Alice to recognize that it is Liam that is at fault and she goes to Lorcan about his behaviour. After being confronted, Liam admits to his drug abuse and it leaves Julia with no option but to suspend him from work. Elsewhere, Aideen doesn't turn up at the airport and later tells Dan to leave her alone. Later Dan is ...

Alice secures a temporary role as the nurse in the clinic, and is keen to celebrate with Dan. Annie Ward brings her ex-boyfriend, Dave, to the night clinic in an effort to wean him off heroin with disastrous consequences.

Fergus Mitchell, a teenager claiming to be Patrick's son is mugged and beaten up and asks for Patrick when at the hospital.But Bernie doubts his story but Patrick isn't swayed. Elsewhere, Julia agrees to run for job of Hospital Director and when she gets the job she offers her shares to Lorcan and Cara steps in as birth partner to Fiona. Meanwhile, Lorcan and Clodagh decide to go out on a date.

Dan and Daisy face Niall Boylan in court but later find out that he has been killed. After Alice lets slip about Lorcan's HIV status Dan confronts him. Later, Dan is arrested for Niall Boylan's murder.

Dan is back with a second chance after surgery but his life is thrown into turmoil when he discovers Cathy is pregnant. It's a tumultuous start for the couple but they finally come together as one and look forward to their future. Cathy is now monitoring Clodagh's every step after her potentially life-threatening diagnosis and this causes tension for Clodagh. Daisy moves in with Conor and starts a relationship with Adam.

Liam's son Ian wants the morning after pill for a girl he had unprotected sex with but, when Liam calls her parents, he is stunned to hear that she claims Ian raped her. Meanwhile, Keelin returns to The Clinic from the U.S. a married woman. Julia's ex Harry arrives back on the scene and Ed changes his mind about selling his half of the building to Cathy and puts it on the market.

Julia is tempted by her ex-husband Harry's overtures to win her back - until she discovers that he has cancer. Dr. Lorcan O'Brien buys Ed's half of the practice and building which annoys Dan. Dan finally goes back to work at the Vico and repairs a knife wound scar on Keith Reid.

Clodagh's birth mother Carol comes to see her with news that her husband Tom is on the warpath and looking for Clodagh's father, Frederick - the man he believes to be responsible for ruining his life. Upset, Clodagh turns Carol away but later at The Clinic Tom shows up and won't leave until Clodagh hears him out. He becomes physically threatening and Lorcan has to step in to remove him from the premises. Carol returns to beg the shaken Clodagh not to get the Gardaí involved and, while Clodagh agrees to this request, she decides its best not to talk to Carol anymore.

Daisy's close friendship with Conor seems increasingly difficult for Adam to accept. But how will Daisy react when Conor admits that he is in love with her? Meanwhile, Cara marks some notes in the petty-cash box with nail polish to get to the bottom of who is stealing the cash. Elsewhere, Dan has another run-in with new doctor, Lorcan, over one of his methadone patients. Paul discovers he has Peripheral Arterial Disease (PAD) - a clogging of the arteries that could cause a heart attach at any time - a diagnosis that causes dis-harmony in Ronan and Keelin's ...

Liam dramatically kicks Cara out of the house when he finds out that she gave his son Ian's girlfriend Lucy the morning-after pill. Clodagh and Keelin are not on speaking terms because of Paul Dunne's legal action against Clodagh. Meanwhile, Cathy diagnosis Cara's friend Mary with clinical bulimia. Elsewhere, Aine is accused of taking petty cash causing her to step down as practice manager. Lorcan eventually finds out that the petty-cash culprit is actually his sister Alice who is back using again.

Daisy and Cara vie for the position of Practice Manager, while two suitors - Conor and Adam - compete for Daisy's affections. Meanwhile, Dan has an uncomfortable run-in with Emer - his nearly one-night stand - outside the Clinic and finds out that she is one of Lorcan's free-clinic patients. Elsewhere, Patrick asks Bernie to move in with him.

Bernie moves in with Patrick, but she soon realises that he isn't ready to co-habit. Meanwhile, new practice manager Cara struggles to cope without a receptionist and Kieran cannot cope without Molly and leaves baby Hope with Cathy. Elsewhere, Dan and Cathy look at a property in the country and Emer has delusions over her relationship with Dan.

Lorcan's sister Alice, who's back using drugs again, begs Lorcan to help her go 'cold turkey'. Although Lorcan knows it's ethically inadvisable to treat his own sister, he reluctantly agrees to help Alice - on condition that she be locked in the flat. No-one at The Clinic can find out what they are up to. Lorcan is so preoccupied with keeping the whole thing quite that he prescribes the wrong medication to a patient with almost disastrous results, not to mention what happens when Alice collapses at the reception desk.

Cathy is confident that she'll finally be able to oust her manipulative business partner and ex-lover, Dan. But her plan backfires when she discovers that her late father bequeathed his stake in the clinic to his secret partner of five years, Dr. Julia Brady.

Aine finds it increasingly difficult to cope with her son Tommy and reacts in a shocking and distressing way. Meanwhile, Cathy deliberately keeps Julia waiting in reception for their meeting. This backfires on Cathy when Dan invites Julia to dinner and sweet-talks her into taking a more permanent position in the Clinic.

The clinic's new nurse, Liam Smith, has a disastrous first day - and worst of all, he gets Dan's back up when he talks one of his patients out of getting rhinoplasty.

Keelin calls off her wedding to Ronan after an argument, while Cathy and Julia clash over Julia's bedside manner. Sinead is diagnosed with endometriosis and Dan collapses after a squash game.

Dan is devastated to discover he has a life-threatening and that the only operation that can cure him may also end his career. He tries to confide his problems to Cathy, but she tells him there is just too much water under the bridge now for them to be friends. Meanwhile, Keelin, with the help of her father, decides to follow Ronan to New York to give their relationship a second chance.

Clodagh makes the decision to reveal her true identity to her birth mother Carol. What Clodagh hasn't taken into account is whether or not the news will be well received.

Patrick refuses to take an agitated Conor for a session after Conor is rude and insults Bernie. Clodagh has had enough with her acupuncture patients and tells Julia she would like to concentrate on her general practice. Daisy is clearly uncomfortable around Jack and calls him a creep under her breath. Cathy is puzzled by the way Dan is acting and agrees to meet him for lunch. Liam teaches his son, Ian, a lesson after he had a few beers and fell over drunk. Ann Marie teases Jack about Clodagh fancying him but Jack tells her she has nothing to worry about.

Daisy thinks she may have been a cause of Conor's break up with his girlfriend, Siobhann, as well as his accident, after Siobhann warns Daisy to stay away from him. Cara tells Daisy that she didn't give Conor the wrong signals. Patrick reassures Daisy she's not to blame for what happened with Conor and needs to talk to him. Daisy talks to Conor and is relieved his self harming had nothing to do with her.

Jack creates a scene in the clinic after finding out that Daisy has accused him of sexual harassment.

Patrick meets his ex-wife. New GP Richard McKenna is struggling to cope at the clinic. Dan sets about seducing Cathy and Keelin uncovers Jean Keown's secret.

Clodagh gets some shocking news, her father had an affair and she was the product of it. Daisy takes a fancy to Brendan's replacement, Will Cafferty. Cathy & Dan's relationship develops further.

Richard is struggling to deal with his wife Annie's illness while trying to keep his home and work life separate.

Things are hotting up as affairs start rising to the surface. Paul tells Keelin he knows about her and Ed and begs her not to say anything to Yvonne about his carry on at the stag party. Meanwhile, Cathy tells Ed she might be pregnant and in turn Ed tells Keelin the news, who lets a congratulations slip to Cathy! Meanwhile, Yvonne hears Keelin and Paul fighting about his stag night antics and loses her temper with Keelin and tells her she doesn't want her to be her bridesmaid any more.