Piers Morgan meets convicted murderer Mark Riebe, a killer who has confessed multiple times to the abduction and murder of 13 young women along Florida's Gulf Coast. Although he is incarcerated for just one murder but has since withdrawn all his confessions, police believe that Mark Riebe is a serial killer who is one of the worst of the kind in Florida's history.

Missouri's most notorious serial killer terrorised the streets of Kansas City for over two decades. In this chilling film, Piers Morgan comes face to face with Lorenzo Gilyard, a seemingly ordinary man who killed 13 times before discarding his victims on the city streets. Although he is serving six life sentences, Gilyard continues to protest his innocence despite overwhelming DNA evidence against him.

Alex Henriquez, a successful businessman from the Bronx in New York City, was convicted of killing three girls but claims he is an innocent man. The three victims had two things in common - they were all asphyxiated before being dumped by the highway, and they could all be placed with Alex Henriquez shortly before their deaths. For nearly 30 years, Henriquez has protested his innocence claiming the police set him up.

In Piers Morgan's previous interviews with convicted serial killers, all protested their innocence. Now, for the first time, Piers comes face-face with a serial killer who is willing to admit to his heinous crimes. Over three months in late 1973, 20-year-old Bernard Giles picked up five innocent young women hitchhiking through his neighbourhood, and slaughtered each of them in cold blood. Fortunate to be spared the death penalty, he will never be released from prison. For one compelling, tension-filled hour, Piers sits down with Giles for the killer's first-ever major television interview, to explore what it was in his psychological make-up that compelled him to commit these brutal crimes.