Mary-Louise Parker (born August 2, 1964) is an American actress and writer. She has won two Golden Globe Awards, a Primetime Emmy Award and a Tony Award.

She is best known for television roles as Nancy Botwin on Showtime's comedy-drama series Weeds (2005–12) and Harper Pitt on the HBO mini-series Angels in America (2003), as well as for film roles in Fried Green Tomatoes (1991), Boys on the Side (1995), The Assassination of Jesse James by the Coward Robert Ford (2007), Red (2010), Red 2 (2013) and Red Sparrow (2018).